When Scarlett gets a sinus infection the week before Homecoming, she never knew that she would be plunged deep into a tangled mess involving the hunky guitar player, Maxx, who goes to her school. She quickly develops a mysterious side effect that appears to cause Maxx to be instantly attracted to her. With her health-freak fashionista friend Izzy by her side, Scarlett searches desperately to find answers about the sketchy "antibiotics" that she took to combat her symptoms. The time clock is set to one week, and between dodging the fiendish escapades of the high school "it-girl" who dates Maxx, as well as the feeble advances of nerdy Greg, Scarlett has to figure out what's real and what's not before anyone she cares about gets hurt.